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Signal Transduction and Targeted Therapy
Preclinical and first-in-human of purinostat mesylate, a novel selective HDAC I/IIb inhibitor, in relapsed/refractory multiple myeloma and lymphoma

10x Genomics Single Cell

Bulk RNA-seq

2025
Mouse
Nature
Amplifying antigen-induced cellular responses with proximity labelling

10x Genomics Single Cell

Bulk RNA-seq

2025
Mouse
Science
Microglia replacement halts the progression of microgliopathy in mice and humans

10x Genomics Single Cell

Bulk RNA-seq

2025
Mouse
Cancer Cell
Chemotherapy awakens dormant cancer cells in lung by inducing neutrophil extracellular traps

10x Genomics Single Cell

10x Genomics Spatial Transcriptomics

2025
Mouse
Cell
Anti-BCMA CAR-T therapy in patients with progressive multiple sclerosis

10x Genomics Single Cell

2025
Human
Cell
Tumor-produced ammonia is metabolized by regulatoryT cells to further impede anti-tumor immunity

10x Genomics Spatial Transcriptomics

2025
Human
Cell
Tuning the sensitivity of mechanosensory receptors through histidine scanning

10x Genomics Single Cell

2026
Mouse
Circulation
Single-Cell Multi-Omics Identifies Specialized Cytotoxic and Migratory CD8+ Effector T Cells in Acute Myocarditis

10x Genomics Single Cell

2025
Human
Molecular Cancer
Single-cell RNA sequencing reveals a reprogramming of hepatic immune cells and a protective role for B cells in MASH-driven HCC

10x Genomics Single Cell

2025
Mouse
Molecular Cancer
Integrated multi-omics identifies a CD54+ iCAF-ITGAL+ macrophage niche driving immunosuppression via CXCL8-PDL1 axis in cervical cancer

10x Genomics Spatial Transcriptomics

2025
Human
Molecular Cancer
Tumor-associated macrophages promote chemoresistance to Paclitaxel via activating NOTCH2-JAG1 juxtacrine signaling

MobiDrop Single Cell

2026
Mouse
Cancer Discovery
Molecular and immune correlates of response to first-line de-escalated chemotherapy plus penpulimab and anlotinib in advanced cervical cancer

10x Genomics Single Cell

2025
Human
Cancer Discovery
Spatiotemporal Immune Determinants of Response to Immune Rechallenge in Advanced Cervical Cancer

10x Genomics Single Cell

2026
Human
iMeta
Single‐cell sequencing reveals the role of IL‐33+ endothelial subsets in promoting early gastric cancer progression

10x Genomics Single Cell

Bulk RNA-seq

2025
Human
iMeta
Neoadjuvant immunotherapy driven bladder preservation for muscle invasive bladder cancer

10x Genomics Single Cell

2025
Human
Cell Metabolism
Itaconate promotes inflammatory responses in tissue-resident alveolar macrophages and exacerbates acute lung injury

10x Genomics Single Cell

2025
Mouse
Nature Genetics
Single-cell and spatial transcriptomics reveal mechanisms of radioresistance and immune escape in recurrent nasopharyngeal carcinoma

10x Genomics Spatial Transcriptomics

2025
Human
Advanced Materials
Artesunate Nanoplatform Targets the Serine-MAPK Axis in Cancer-Associated Fibroblasts to Reverse hotothermal Resistance in Triple-Negative Breast Cancer

10x Genomics Single Cell

10x Genomics Spatial Transcriptomics

2025
Mouse
Advanced Materials
LPS-Binding Hydrogel for TLR4-Mediated Microbiota-Immune Modulation

MobiDrop Single Cell

2025
Mouse
Immunity
Nociceptor-derived CGRP enhances dermal type I conventional dendritic cell function to drive autoreactive CD8+ T cell responses in vitiligo

10x Genomics Spatial Transcriptomics

2025
Human
Gut
Hypothesis-generating evaluation of multi-armoured oncolytic HSV-1 (VG161) in intrahepatic cholangiocarcinoma: pooled insights from multicentre studies

10x Genomics Single Cell

2025
Human
Cancer Communications
CD24 is a promising immunotherapeutic target for enhancing efficacy of third-generation EGFR-TKIs on EGFR-mutated lung cancer

Bulk RNA-seq

MobiDrop Single Cell

2025
Human
Bioactive Materials
Dual itaconate delivery systems modulate macrophage Acod1-Hif-1α-glycolysis axis for immunotherapy of bioprosthetic heart valve calcification

10x Genomics Single Cell

10x Genomics Spatial Transcriptomics

2025
Human
Mouse
Nature Neuroscience
Spinal cord Tau pathology induces tactile deficits and cognitive impairment in Alzheimer’s disease via dysregulation of CCK neurons

10x Genomics Single Cell

2025
Mouse
Cellular & Molecular Biology Letters
Sexual dimorphism of lung immune-regulatory units imprint biased pulmonary fibrosis

10x Genomics Single Cell

2025
Mouse
Nature Aging
Extracellular vesicles from antler blastema progenitor cells reverse bone loss and mitigate aging-related phenotypes in mice and macaques

10x Genomics Single Cell

2025
Rhesus macaque
Cancer Research
USP20-Driven Cholesterol Metabolism Links Inflammatory Signaling to Malignancy and Stromal Co-evolution in Pancreatic Cancer

10x Genomics Spatial Transcriptomics

2025
Mouse
Circulation Research
GUCY1A1-LDHA Axis Suppresses Ferroptosis in Cardiac Ischemia-Reperfusion Injury

10x Genomics Single Cell

Bulk RNA-seq

2025
Mouse
ACS Nano
Effect of Engineered Cyanobacterial Capsules on a Neurogenic Bladder after Spinal Cord Injury

10x Genomics Single Cell

Bulk RNA-seq

2025
Rat
ACS Nano
Multi-Activity Nanozyme-Integrated Scaffolds: Harnessing Synergistic Enzyme-like Effects for Complete Treatment of Infected Bone Defects

10x Genomics Single Cell

2026
Rat
Hepatology
MIF-mediated crosstalk between THRSP+ hepatocytes and CD74+ lipid-associated macrophages in hepatic periportal zone drives MASH

10x Genomics Single Cell

2025
Human
Hepatology
Tumor microenvironment heterogeneity and progression mechanisms in intrahepatic cholangiocarcinoma: A study based on single-cell and spatial transcriptomic sequencing

10x Genomics Single Cell

10x Genomics Spatial Transcriptomics

2025
Human
Nature Communications
Efhcacy, safety and single-cell analysis of neoadjuvant immunochemotherapy in locally advanced oral squamous cel carcinoma: a phase I trial

10x Genomics Single Cell

2025
Human
Nature Communications
Single-nucleus transcriptomics reveal the morphogenesis and artemisinin biosynthesis in Artemisia annua glandular trichomes

10x Genomics Single Cell

2025
Artemisia annua
Nature Communications
Metabolic support protects mucosa from ferroptosis in radiation-induced mucositis

10x Genomics Single Cell

2025
Mouse
Nature Communications
Exercise-induced histone lactylation in monocyte-derived macrophages restores cardiac immune homeostasis and function in sepsis-induced cardiomyopathy

10x Genomics Single Cell

2025
Mouse
Nature Communications
enascin C+ myofibroblasts exacerbate vascular neointimal hyperplasia by propagation of nerve-macrophage interactions in mice

10x Genomics Spatial Transcriptomics

2026
Mouse
npj Digital Medicine
Machine learning-enabled spatial multi-omics uncovers lactate-driven targets and tumor microenvironmental reprogramming in cancer

10x Genomics Single Cell

10x Genomics Spatial Transcriptomics

2025
Human
Neuron
Globally patterned locus coeruleus-norepinephrine neuron-pericyte coupling orchestrates brain-wide vascular dynamics

10x Genomics Single Cell

2025
Zebrafish
Science Translational Medicine
Myeloid MAS–driven macrophage efferocytosis promotes resolution in ischemia-stressed mouse and human livers

10x Genomics Single Cell

10x Genomics Spatial Transcriptomics

2025
Mouse
Advanced Science
Unraveling the Microenvironment and the Pathogenic Axis of HIF-1a–Visfatin–Fibrosis in Autoimmune Pancreatitis Using a Single-Cell Atlas

MobiDrop Single Cell

2025
Human
Advanced Science
Mesencephalic Astrocyte-Derived Neurotrophic Factor Binds BAX to Preserve Mitochondrial Homeostasis and Energy Metabolism for Relieving Myocardial Hypertrophy

10x Genomics Single Cell

2025
Mouse
Advanced Science
M2 Macrophage-Derived Extracellular Vesicles Reprogram lmmature Neutrophils into Anxalhi Neutrophils to Enhance Inflamed Bone Regeneration

10x Genomics Single Cell

2025
Mouse
Advanced Science
The High-Altitude Adaptation Characteristics of Microbiota-Host Cross-Talk in Yak Gastrointestina Track

10x Genomics Single Cell

2025
Yak
Advanced Science
Smoking-Induced STC2+ Tumor Cells Drive Tumor-Vascular Crosstalk in Laryngeal Squamous Cell Carcinoma via Spatial and Single-Cell Transcriptomics

10x Genomics Single Cell

10x Genomics Spatial Transcriptomics

2025
Human
Advanced Science
From Invaginating Site to Deep Lesion: Spatial Transcriptomics Unravels Ectopic Endometrial Penetration Features in Adenomyosis

10x Genomics Spatial Transcriptomics

2025
Human
Advanced Science
Scale-Up ofHuman Amniotic Epithelial Cells Through Regulation ofEpithelial-Mesenchymal Plasticity Under Defined Conditions

10x Genomics Single Cell

2025
Human
Advanced Science
dentification of a Force-Induced Sox9+Acan+ Transitional Subpopulation Linked to FGF2-FGFR2-ERK Signaling in Orthodontic Bone Remodeling

10x Genomics Single Cell

2026
Mouse
Advanced Science
Identification and Mechanisms of Osteocyte Subsets Involved in the Pathological Progression of Osteoporosis

10x Genomics Single Cell

2026
Mouse
Advanced Science
UBE2T-Driven p53 Degradation Rewires Glycolysis to Orchestrate Lactylation-Mediated CAFs Activation and ECM Deposition in Pancreatic Cancer

10x Genomics Single Cell

2026
Mouse
Advanced Science
Targeting the CMKLR1-Mediated Signaling Rebalances Immunometabolism State in Middle-Age Testicular Macrophages

10x Genomics Single Cell

2026
Human
Mouse
Advanced Science
Pancancer Fine-Mapping of Mutational Intolerance Identifies CHEK1 as an Immunosuppressive Driver in Lung Adenocarcinoma

MobiDrop Single Cell

2026
Mouse
Journal of Clinical Investigation
ZEB1 promotes chemo-immune resistance in pancreatic cancer models by downregulating chromatin acetylation of CXCL16

10x Genomics Single Cell

10x Genomics Spatial Transcriptomics

2025
Mouse
Leukemia
asxl1 C-terminal truncation and SRSF2 mutation drive leukemogenesis via immune reprogramming

10x Genomics Single Cell

2025
Zebrafish
Theranostics
Boosting mRNA cancer vaccine efficacy via targeting Irg1 on macrophages in lymph nodes

MobiDrop Single Cell

2025
Mouse
Theranostics
Luminal Stem-like Cells in High-Risk/Locally Advanced Prostate Cancer Promote Resistance to Hormonal Therapy

10x Genomics Single Cell

2025
Human
Theranostics
PTEN-mediated senescence of lung epithelial cells drives ventilator-induced pulmonary fibrosis

10x Genomics Single Cell

2025
Mouse
Theranostics
Pathogenomic analysis reveals clinically relevant epithelial-mesenchymal plasticity in esophageal squamous cell carcinoma

10x Genomics Spatial Transcriptomics

2026
Human
Journal of Advanced Research
Spatial multi-omics guides ASCT2-targeted delivery of glycolysis inhibitor for cervical cancer suppression and chemoresistance reversal

10x Genomics Spatial Transcriptomics

2025
Human
Journal of Advanced Research
Illustrating the functional heterogeneity of M-MDSCs to predict sepsis outcomes

10x Genomics Single Cell

2026
Human
Journal of Nanobiotechnology
Biomimetic phosphorus dendrimer multi epitope nanovaccine enhances humoral and cellular immune response against African swine fever virus

MobiDrop Single Cell

2025
Mouse
Journal of Nanobiotechnology
Human adipose-derived mesenchymal stem cell-derived exosomes induce epithelial remodeling and anti-scar healing revealed by single-cell RNA sequencing | Journal of Nanobiotechnology

10x Genomics Single Cell

2025
Mouse
Science Advances
Targeting tumor-associated CCR2+ macrophages to inhibit pancreatic cancer recurrence following irreversible electroporation

10x Genomics Single Cell

2025
Mouse
Cell Discovery
Breast cancer induces CD62L+ Kupffer cells via DMBT1 to promote neutrophil extracellular trap formation and liver metastasis

10x Genomics Single Cell

2025
Mouse
Science Advances
BCMA/CD19 CAR T cell therapy for refractory myasthenia gravis: Proteomic signatures and single-cell transcriptomics of disease flares

10x Genomics Single Cell

2026
Human
International Journal of Oral Science
Single-cell transcriptomics identifies PDGFRA+ progenitors orchestrating angiogenesis and periodontal tissue regeneration

10x Genomics Single Cell

2025
Human
Med
Anti-BCMA CAR-T cell therapy in relapsed/refractory chronic inflammatory demyelinating polyneuropathy

10x Genomics Single Cell

2025
Human
Biomarker Research
Integrating single-cell RNA sequencing and spatial multi-omics reveals the molecular signature of regeneration after spinal cord injury

10x Genomics Single Cell

10x Genomics Spatial Transcriptomics

2025
Rat
Ebiomedicine
Skeletal muscle-derived lL-33 mediates muscle-to-bone crosstalk and regulates bone metabolism via CD8 T cell-secreted CCL5

MobiDrop Single Cell

2025
Rat
Research
Neonatal-Inspired Reprogramming of Microglial Pan-Programmed Cell Death Enhances Regeneration in Adult Spinal Cord Injury

MobiDrop Single Cell

2025
Mouse
MedComm
Spatial Transcriptional Heterogeneity in the Infarct Core and Its Surrounding Regions Targeting Piezo1 Signals in Rats With Myocardial Ischemia-Reperfusion Injury

10x Genomics Single Cell

10x Genomics Spatial Transcriptomics

2026
Rat
Cell Reports Medicine
Ce6 derivative photodynamic therapy triggers PANoptosis and enhances antitumor immunity with LAG3 blockade in cutaneous squamous cell carcinoma

10x Genomics Spatial Transcriptomics

Bulk RNA-seq

2025
Mouse
Cell Reports Medicine
High cellular plasticity state of medulloblastoma local recurrence and distant dissemination

10x Genomics Single Cell

10x Genomics Spatial Transcriptomics

2025
Human
Cell Reports Medicine
Interferon-driven CAF reprogramming augments immunogenic response to neoadjuvant radiotherapy in colorectal cancer

10x Genomics Single Cell

Bulk RNA-seq

2025
Mouse
Plant Biotechnology Journal
Mass Spectrometry Imaging Combined with Single-Cell Transcriptional Profiling Reveals the Multidimensional Spatial Distributions and Biosynthetic Pathways of Medicinal Components in Andrographis paniculata

10x Genomics Single Cell

2026
Andrographis paniculata
Cellular & Molecular Immunology
Immunodynamic axis of fbroblast-driven neutrophil infltration in acute pancreatitis: NF-κB–HIF-1α–CXCL1

10x Genomics Single Cell

2025
Mouse
International Journal of Biological Macromolecules
Itaconate Modulates Neutrophil Homeostasis to Ameliorate Airway Inflammation in Diesel Exhaust Particles-exacerbated Asthma via Inhibiting NETs Formation

Bulk RNA-seq

MobiDrop Single Cell

2026
Mouse
npj Biofilms and Microbiomes
Disruption of bile acid homeostasis potentiates Paneth cell ablation by activating the intestinal Farnesoid X receptor in necrotizing enterocolitis

MobiDrop Single Cell

2026
Mouse
Proceedings of the National Academy of Sciences of the United States of America
Disruption of bile acid homeostasis potentiates Paneth cell ablation by activating the intestinal Farnesoid X receptor in necrotizing enterocolitis_copy20260314125136Setdb1 ablation in macrophages attenuates fibrosis in heart allografts

10x Genomics Single Cell

Bulk RNA-seq

2025
Mouse
PNAS
Blood-abyrinth barrier damage mediated by granzymes from cytotoxic lymphocytes results in hearing loss in systemic lupus erythematosus

10x Genomics Single Cell

2025
Mouse
PNAS
Spatially resolved multiomics reveals the self-enforcing property of the leading-edge multicellular ecosystem of head and neck cancer

10x Genomics Single Cell

10x Genomics Spatial Transcriptomics

2026
Human
International Journal of Biological Macromolecules
Single-cell transcriptomics reveals extracellular matrix remodeling and collagen dynamics during lactation in sheep mammary gland

10x Genomics Single Cell

2025
Sheep
Horticulture Research
Spatiotemporally transcriptomic analyses of floral buds reveal the high-resolution landscape of flower development and dormancy regulation in peach

10x Genomics Spatial Transcriptomics

2025
Peach
Phytomedicine
Dalbergia odorifera T.C. Chen Leaf Extract Promotes Microglial Energy Expenditure to Phagocytize Neutrophils After Cerebral Ischemia-reperfusion

10x Genomics Single Cell

2025
Mouse
npj Precision Oncology
ECT2+ cell group acts as cancer stem cell in malignant pleomorphic adenoma

10x Genomics Single Cell

2025
Human
Journal of Translational Medicine
A dynamic molecular landscape in colorectal cancer progression at single-cell resolution

10x Genomics Single Cell

2025
Human
Journal of Translational Medicine
Spatial multi-omics profiling uncovers metabolic heterogeneity in Sjögren’s syndrome and identifies PS(36:1) as a potential therapeutic target

10x Genomics Single Cell

10x Genomics Spatial Transcriptomics

2025
Human
Aging Cell
Spatial Transcriptomic characteristics of the Aging Human ovary

10x Genomics Single Cell

Stereo-seq Spatial Transcriptomics

2025
Human
Cell Reports
Single-nucleus profiling of mouse inner ear aging uncovers cell type heterogeneity and hair cell subtype-specific age-related signatures

10x Genomics Single Cell

2025
Mouse
Journal of Clinical Periodontology
Periodontitis Induces Arterial Microbiota Shifts and Immune Dysregulation Contributing to Peripheral Vascular Inflammation

MobiDrop Single Cell

2025
Mouse
Journal of Animal Science and Biotechnology
Dissecting the development of bovine testicular tissue using spatial transcriptomics

Stereo-seq Spatial Transcriptomics

2026
Cattle
Plant Cell and Environment
Single‐Cell RNA Sequencing Reveals the Developmental Landscape of Wheat Roots

10x Genomics Single Cell

2025
Wheat
Cell and Bioscience
Single-cell sequencing combined with spatial transcriptomics reveals the characteristics of follicle-targeted inflammation patterns in primary cicatricial alopecia

10x Genomics Spatial Transcriptomics

2025
Human
Industrial Crops and Products
Unveiling the development of cotton somatic embryos: Integrating spatial transcriptomics and metabolomics

10x Genomics Spatial Transcriptomics

2025
Cotton
Journal of Dental Research
Schwann Cell-Secreted S100B Promotes Wound Healing via Paracrine Modulation

10x Genomics Single Cell

2025
Cynomolgus macaque
Journal of Dental Research
Decoding Spatiotemporal Microenvironmental Changes in Oral Carcinogenesis

10x Genomics Single Cell

10x Genomics Spatial Transcriptomics

2025
Human
Frontiers in Bioengineering and Biotechnology
Humoral immune activation within tertiary lymphoid structures is correlated with poor outcomes in oral lichen planus and lichenoid lesions

10x Genomics Spatial Transcriptomics

2025
Human
Virulence
Single-cell RNA sequencing reveals T and B cell related immune features in foot and mouth disease virus-infected mice

10x Genomics Single Cell

2025
Mouse
Journal of the American Heart Association
Single-Cell RNA Sequencing Reveals Granzyme K+ CD8+ T Cells as a Target for Mitigating Plaque Instability Following Radiation

10x Genomics Single Cell

2025
Mouse
Frontiers in Bioengineering and Biotechnology
The landscape of cell regulatory and communication networks in the human dental follicle

10x Genomics Single Cell

2025
Human
Zoological Research
The integration of spatial transcriptomics and metabolic data from the cortical region of the brain identifies key genes associated with cognitive ability in pigs

10x Genomics Spatial Transcriptomics

2025
Pig
Plant Cell Reports
Single-cell transcriptional decoding of iron deficiency responses in maize root tips

10x Genomics Single Cell

2025
Maize
Frontiers in Bioengineering and Biotechnology
Spatial metabolomics and transcriptomics reveal cell type-specific dynamics in the placenta of patients with late-onset preeclampsia

10x Genomics Spatial Transcriptomics

2025
Human
BBA - Molecular Basis of Disease
Single-cell RNA-seq reveals the immune profile changes in patients with diarrhoeal-irritable bowel syndrome

10x Genomics Single Cell

2025
Human
iScience
CRISPR/Cas9-mediated SHP-1-knockout T cells combined with simvastatin enhances anti-tumor activity in humanized-PDX HCC model

10x Genomics Single Cell

2025
Human
iScience
Integrated spatial omics of metabolic reprogramming and the tumor microenvironment in pancreatic cancer

10x Genomics Spatial Transcriptomics

2025
Human
Life Metabolism
Intestinal epithelial formyl peptide receptor 2 contributes to intestinal epithelium homeostasis and injury repair by regulating intestinal stem cell and transit-amplifying cell proliferation and differentiation

MobiDrop Single Cell

2025
Mouse
Science
A wheat tandem kinase activates an NLR to trigger immunity

Yeast Library

2025
Wheat
Nature
A kinase mediator of rhizobial symbiosis and immunity in Medicago

Yeast Library

2025
Alfalfa
Nature
Releasing a sugar brake generates sweeter tomato without yield penalty

Yeast Library

2024
Tomato
Science
Enhanced sustainable green revolution yield via nitrogen-responsive chromatin modulation in rice

Yeast Library

2020
Rice
Nature Plants
MdBT2 regulates nitrogen-mediated cuticular wax biosynthesis via a MdMYB106-MdCER2L1 signalling pathway in apple

Yeast Library

2024
Apple
Nature Communications
Transfer learning enables identification of multiple types of RNA modifications using nanopore direct RNA sequencing

Yeast Library

2024
Rice
Plant Biotechnology Journal
PagARGOS promotes low-lignin wood formation in poplar

Yeast Library

2024
Poplar
Oncolytic virus VG161 in refractory hepatocellular carcinoma
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