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Artesunate Nanoplatform Targets the Serine-MAPK Axis in Cancer-Associated Fibroblasts to Reverse hotothermal Resistance in Triple-Negative Breast Cancer

LPS-Binding Hydrogel for TLR4-Mediated Microbiota-Immune Modulation

Nociceptor-derived CGRP enhances dermal type I conventional dendritic cell function to drive autoreactive CD8+ T cell responses in vitiligo

Hypothesis-generating evaluation of multi-armoured oncolytic HSV-1 (VG161) in intrahepatic cholangiocarcinoma: pooled insights from multicentre studies

CD24 is a promising immunotherapeutic target for enhancing efficacy of third-generation EGFR-TKIs on EGFR-mutated lung cancer

Dual itaconate delivery systems modulate macrophage Acod1-Hif-1α-glycolysis axis for immunotherapy of bioprosthetic heart valve calcification

Spinal cord Tau pathology induces tactile deficits and cognitive impairment in Alzheimer’s disease via dysregulation of CCK neurons

Sexual dimorphism of lung immune-regulatory units imprint biased pulmonary fibrosis

Extracellular vesicles from antler blastema progenitor cells reverse bone loss and mitigate aging-related phenotypes in mice and macaques

USP20-Driven Cholesterol Metabolism Links Inflammatory Signaling to Malignancy and Stromal Co-evolution in Pancreatic Cancer

GUCY1A1-LDHA Axis Suppresses Ferroptosis in Cardiac Ischemia-Reperfusion Injury

Effect of Engineered Cyanobacterial Capsules on a Neurogenic Bladder after Spinal Cord Injury

Multi-Activity Nanozyme-Integrated Scaffolds: Harnessing Synergistic Enzyme-like Effects for Complete Treatment of Infected Bone Defects

MIF-mediated crosstalk between THRSP+ hepatocytes and CD74+ lipid-associated macrophages in hepatic periportal zone drives MASH

Tumor microenvironment heterogeneity and progression mechanisms in intrahepatic cholangiocarcinoma: A study based on single-cell and spatial transcriptomic sequencing

Efhcacy, safety and single-cell analysis of neoadjuvant immunochemotherapy in locally advanced oral squamous cel carcinoma: a phase I trial

Single-nucleus transcriptomics reveal the morphogenesis and artemisinin biosynthesis in Artemisia annua glandular trichomes

Metabolic support protects mucosa from ferroptosis in radiation-induced mucositis

Exercise-induced histone lactylation in monocyte-derived macrophages restores cardiac immune homeostasis and function in sepsis-induced cardiomyopathy

enascin C+ myofibroblasts exacerbate vascular neointimal hyperplasia by propagation of nerve-macrophage interactions in mice

Machine learning-enabled spatial multi-omics uncovers lactate-driven targets and tumor microenvironmental reprogramming in cancer

Globally patterned locus coeruleus-norepinephrine neuron-pericyte coupling orchestrates brain-wide vascular dynamics

Myeloid MAS–driven macrophage efferocytosis promotes resolution in ischemia-stressed mouse and human livers

Unraveling the Microenvironment and the Pathogenic Axis of HIF-1a–Visfatin–Fibrosis in Autoimmune Pancreatitis Using a Single-Cell Atlas

Mesencephalic Astrocyte-Derived Neurotrophic Factor Binds BAX to Preserve Mitochondrial Homeostasis and Energy Metabolism for Relieving Myocardial Hypertrophy

M2 Macrophage-Derived Extracellular Vesicles Reprogram lmmature Neutrophils into Anxalhi Neutrophils to Enhance Inflamed Bone Regeneration

The High-Altitude Adaptation Characteristics of Microbiota-Host Cross-Talk in Yak Gastrointestina Track

Smoking-Induced STC2+ Tumor Cells Drive Tumor-Vascular Crosstalk in Laryngeal Squamous Cell Carcinoma via Spatial and Single-Cell Transcriptomics

From Invaginating Site to Deep Lesion: Spatial Transcriptomics Unravels Ectopic Endometrial Penetration Features in Adenomyosis

Scale-Up ofHuman Amniotic Epithelial Cells Through Regulation ofEpithelial-Mesenchymal Plasticity Under Defined Conditions

dentification of a Force-Induced Sox9+Acan+ Transitional Subpopulation Linked to FGF2-FGFR2-ERK Signaling in Orthodontic Bone Remodeling

Identification and Mechanisms of Osteocyte Subsets Involved in the Pathological Progression of Osteoporosis

UBE2T-Driven p53 Degradation Rewires Glycolysis to Orchestrate Lactylation-Mediated CAFs Activation and ECM Deposition in Pancreatic Cancer

Targeting the CMKLR1-Mediated Signaling Rebalances Immunometabolism State in Middle-Age Testicular Macrophages

Pancancer Fine-Mapping of Mutational Intolerance Identifies CHEK1 as an Immunosuppressive Driver in Lung Adenocarcinoma

ZEB1 promotes chemo-immune resistance in pancreatic cancer models by downregulating chromatin acetylation of CXCL16

asxl1 C-terminal truncation and SRSF2 mutation drive leukemogenesis via immune reprogramming

Boosting mRNA cancer vaccine efficacy via targeting Irg1 on macrophages in lymph nodes

Luminal Stem-like Cells in High-Risk/Locally Advanced Prostate Cancer Promote Resistance to Hormonal Therapy

PTEN-mediated senescence of lung epithelial cells drives ventilator-induced pulmonary fibrosis

Pathogenomic analysis reveals clinically relevant epithelial-mesenchymal plasticity in esophageal squamous cell carcinoma

Spatial multi-omics guides ASCT2-targeted delivery of glycolysis inhibitor for cervical cancer suppression and chemoresistance reversal

Illustrating the functional heterogeneity of M-MDSCs to predict sepsis outcomes

Biomimetic phosphorus dendrimer multi epitope nanovaccine enhances humoral and cellular immune response against African swine fever virus

Human adipose-derived mesenchymal stem cell-derived exosomes induce epithelial remodeling and anti-scar healing revealed by single-cell RNA sequencing | Journal of Nanobiotechnology

Targeting tumor-associated CCR2+ macrophages to inhibit pancreatic cancer recurrence following irreversible electroporation

Breast cancer induces CD62L+ Kupffer cells via DMBT1 to promote neutrophil extracellular trap formation and liver metastasis

BCMA/CD19 CAR T cell therapy for refractory myasthenia gravis: Proteomic signatures and single-cell transcriptomics of disease flares

Single-cell transcriptomics identifies PDGFRA+ progenitors orchestrating angiogenesis and periodontal tissue regeneration

Anti-BCMA CAR-T cell therapy in relapsed/refractory chronic inflammatory demyelinating polyneuropathy

Integrating single-cell RNA sequencing and spatial multi-omics reveals the molecular signature of regeneration after spinal cord injury

Skeletal muscle-derived lL-33 mediates muscle-to-bone crosstalk and regulates bone metabolism via CD8 T cell-secreted CCL5

Neonatal-Inspired Reprogramming of Microglial Pan-Programmed Cell Death Enhances Regeneration in Adult Spinal Cord Injury

Spatial Transcriptional Heterogeneity in the Infarct Core and Its Surrounding Regions Targeting Piezo1 Signals in Rats With Myocardial Ischemia-Reperfusion Injury

Ce6 derivative photodynamic therapy triggers PANoptosis and enhances antitumor immunity with LAG3 blockade in cutaneous squamous cell carcinoma

High cellular plasticity state of medulloblastoma local recurrence and distant dissemination

Interferon-driven CAF reprogramming augments immunogenic response to neoadjuvant radiotherapy in colorectal cancer

Mass Spectrometry Imaging Combined with Single-Cell Transcriptional Profiling Reveals the Multidimensional Spatial Distributions and Biosynthetic Pathways of Medicinal Components in Andrographis paniculata

Immunodynamic axis of fbroblast-driven neutrophil infltration in acute pancreatitis: NF-κB–HIF-1α–CXCL1

Itaconate Modulates Neutrophil Homeostasis to Ameliorate Airway Inflammation in Diesel Exhaust Particles-exacerbated Asthma via Inhibiting NETs Formation

Disruption of bile acid homeostasis potentiates Paneth cell ablation by activating the intestinal Farnesoid X receptor in necrotizing enterocolitis

Disruption of bile acid homeostasis potentiates Paneth cell ablation by activating the intestinal Farnesoid X receptor in necrotizing enterocolitis_copy20260314125136Setdb1 ablation in macrophages attenuates fibrosis in heart allografts

Blood-abyrinth barrier damage mediated by granzymes from cytotoxic lymphocytes results in hearing loss in systemic lupus erythematosus

Spatially resolved multiomics reveals the self-enforcing property of the leading-edge multicellular ecosystem of head and neck cancer

Single-cell transcriptomics reveals extracellular matrix remodeling and collagen dynamics during lactation in sheep mammary gland

Spatiotemporally transcriptomic analyses of floral buds reveal the high-resolution landscape of flower development and dormancy regulation in peach

Dalbergia odorifera T.C. Chen Leaf Extract Promotes Microglial Energy Expenditure to Phagocytize Neutrophils After Cerebral Ischemia-reperfusion

ECT2+ cell group acts as cancer stem cell in malignant pleomorphic adenoma

A dynamic molecular landscape in colorectal cancer progression at single-cell resolution

Spatial multi-omics profiling uncovers metabolic heterogeneity in Sjögren’s syndrome and identifies PS(36:1) as a potential therapeutic target

Spatial Transcriptomic characteristics of the Aging Human ovary

Single-nucleus profiling of mouse inner ear aging uncovers cell type heterogeneity and hair cell subtype-specific age-related signatures

Periodontitis Induces Arterial Microbiota Shifts and Immune Dysregulation Contributing to Peripheral Vascular Inflammation

Dissecting the development of bovine testicular tissue using spatial transcriptomics

Single‐Cell RNA Sequencing Reveals the Developmental Landscape of Wheat Roots

Single-cell sequencing combined with spatial transcriptomics reveals the characteristics of follicle-targeted inflammation patterns in primary cicatricial alopecia

Unveiling the development of cotton somatic embryos: Integrating spatial transcriptomics and metabolomics

Schwann Cell-Secreted S100B Promotes Wound Healing via Paracrine Modulation

Decoding Spatiotemporal Microenvironmental Changes in Oral Carcinogenesis

Humoral immune activation within tertiary lymphoid structures is correlated with poor outcomes in oral lichen planus and lichenoid lesions

Single-cell RNA sequencing reveals T and B cell related immune features in foot and mouth disease virus-infected mice

Single-Cell RNA Sequencing Reveals Granzyme K+ CD8+ T Cells as a Target for Mitigating Plaque Instability Following Radiation

The landscape of cell regulatory and communication networks in the human dental follicle

The integration of spatial transcriptomics and metabolic data from the cortical region of the brain identifies key genes associated with cognitive ability in pigs

Single-cell transcriptional decoding of iron deficiency responses in maize root tips

Spatial metabolomics and transcriptomics reveal cell type-specific dynamics in the placenta of patients with late-onset preeclampsia

Single-cell RNA-seq reveals the immune profile changes in patients with diarrhoeal-irritable bowel syndrome

CRISPR/Cas9-mediated SHP-1-knockout T cells combined with simvastatin enhances anti-tumor activity in humanized-PDX HCC model

Integrated spatial omics of metabolic reprogramming and the tumor microenvironment in pancreatic cancer

Intestinal epithelial formyl peptide receptor 2 contributes to intestinal epithelium homeostasis and injury repair by regulating intestinal stem cell and transit-amplifying cell proliferation and differentiation

A wheat tandem kinase activates an NLR to trigger immunity

A kinase mediator of rhizobial symbiosis and immunity in Medicago

Releasing a sugar brake generates sweeter tomato without yield penalty

Enhanced sustainable green revolution yield via nitrogen-responsive chromatin modulation in rice

MdBT2 regulates nitrogen-mediated cuticular wax biosynthesis via a MdMYB106-MdCER2L1 signalling pathway in apple

Transfer learning enables identification of multiple types of RNA modifications using nanopore direct RNA sequencing

PagARGOS promotes low-lignin wood formation in poplar

Oncolytic virus VG161 in refractory hepatocellular carcinoma